ABSTRACT
The present study was carried out involving 25 patients with paucibacillary leprosy who attended the outpatient department of dermatology of Father Muller's Medical College Hospital during the period January 2001 to March 2002. All the patients were examined clinically and histopathologically at the beginning and at the end of six months of MDT and relevant data recorded. Clinicopathological correlation with histopathological classification before MDT was 72% and 68% at the end of MDT in our study. At the end of treatment 4 (16%) cases were clinically active and 8 (32%) were histopathologlcally active. The study showed that active cases were significantly reduced as a result of MDT, both clinically and histopathologically. The histopathological activity that outlasts MDT may be due to the bacillary fragments that persist; but clinical activity coupled with histopathological activity seen in 2 patients at the end of 6 months of MDT was possibly an indicator of relapse and these patients and similar others need to be followed up for a longer duration. In this study, resolution of granuloma and clinical activity after completion of MDT were assessed.
Subject(s)
Adolescent , Adult , Child , Child, Preschool , Dapsone/administration & dosage , Drug Administration Schedule , Drug Therapy, Combination , Female , Humans , Leprostatic Agents/therapeutic use , Leprosy, Lepromatous/classification , Leprosy, Tuberculoid/classification , Male , Middle Aged , Rifampin/administration & dosage , Treatment OutcomeABSTRACT
Objetico: Determinar a prevalencia de olho seco em portadores de hanseniase do Hospital de Dermatologia Sanitaria de Goiania, comparando-se a um grupo controle. Desenho: Estudo de prevalencia. Material e metodos: A amostra do presente estudo inclui 70 portadores de hanseniase, do Hospital de Dermatologia Sanitaria de Goiania, e 30 individuos no grupo controle, da Fundacao Banco de Olhos de Goias, ambos localizados em Goiania-GO. Foram realizados exeme oftalmologico e testes de Schirmer I, break-up time (BUT) e rosa bengala em todos estes individuos em uma unica avaliacao. Resultados: Quarenta e quatro (63,0%) portadores de hanseniase eram do sexo masculino e 22 73,3%) individuos do grupo controle, do sexo feminino (p=0,001). A idade medica dos hansenianos foi de 61,1+-12,5 anos e no grupo controle, 55,7+-9,6 anos. Quinze (21,4%) hansenianos e quatro (13,3%) individuos deo grupo controle apresentaram diagnostico de olho seco (p=0,429) A forma virchowiana (74,2%) da hanseniase foi a mais prevalente e o olho seco (66,7%) foi mais frequente nesta forma clinica da doenca. Conclusao: A prevalencia de olho seco nos portadores de hanseniase foi semelhante a encontrada nos individuos do grupo controle
Subject(s)
Humans , Leprosy, Borderline/classification , Leprosy, Borderline/diagnosis , Leprosy, Borderline/epidemiology , Leprosy, Tuberculoid/classification , Leprosy, Tuberculoid/diagnosis , Leprosy, Tuberculoid/epidemiology , Dry Eye Syndromes/classification , Dry Eye Syndromes/diagnosis , Dry Eye Syndromes/epidemiology , Mycobacterium leprae/classificationSubject(s)
Lepromin/classification , Lepromin/immunology , Erythema Nodosum , Leprosy, Borderline/classification , Leprosy, Borderline/diagnosis , Leprosy, Tuberculoid/classification , Leprosy, Tuberculoid/diagnosis , Leprosy, Lepromatous/diagnosis , Sulfones/administration & dosage , Sulfones/adverse effects , Clofazimine/administration & dosage , Clofazimine/adverse effects , Diagnosis, Differential , Leprosy , Mycobacterium leprae/classification , Mycobacterium leprae/ultrastructure , Rifampin/administration & dosage , Rifampin/adverse effectsABSTRACT
A leprosy survey carried out in a district prison revealed a gross prevalence of 20 cases per 1000, and active prevalence of 10 cases per 1000 whereas, prevalence of leprosy in the state was 1.12 per 1000. Such prisons thus form hyperendemic pockets. The inmates are a closed community and there is a risk of cases among inmates spreading infection to others inside the prison during their sojourn there and to the community when they are released from the prison. Special efforts are required to identify and eliminate all identifiable sources of infection, especially at this point of time when we are aiming at elimination of leprosy as a public health problem.
Subject(s)
Humans , Leprosy, Borderline/classification , Leprosy, Lepromatous/classification , Leprosy, Tuberculoid/classification , Mass Screening , Prisoners , PrisonsABSTRACT
One hundred twenty histologically confirmed cases of leprosy having macular lesions were evaluated clinically and histopathologically according to Ridley-Jopling classification. Of these 120 cases, the majority (91 or 75.8%) were young adults. The main clinical findings were: a single macule in 42 patients (35%), multiple macules 2-5 in numbers in 35 patients (29.1%), 6-10 macules in 17 patients (14.1%) and more than 10 macules in 26 patients (21.6%). Impairment of sensation over the macular lesions was present in 62 cases (51.6%), total loss of sensation was noticed in 31 patients (25.8%) and sensation was intact in 27 patients (22.5%). Acid-fast bacilli were detected in 11 cases (9.1%) by slit-skin smear examination. Clinical examination of the 120 cases revealed features of TT in 16 (13.3%), BT in 41 (34.1%), BB in 11 (9.1%), BL in 13 (10.8%), LL in 7 (5.8%) and indeterminate leprosy (IL) in 32 patients (26.6%). On the contrary, histologically there were 22 cases of TT (18.3%), 38 cases of BT (31.6%), 8 (6.5%) BB, 10 BL (8.3%), 7 LL (5.8%) and 35 cases of IL (29.1%). Histopathological features were consistent with the clinical picture in 84 patients (70%).